Open AccessTwo sisters with mal de meleda: Case series report
Author(s) -
Dua Cebeci,
Seide Karasel,
Görgün Bayraktaroglu
Publication year - 2022
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_812_21
Subject(s) - palmoplantar keratoderma , dermatology , brachydactyly , keratoderma , consanguinity , medicine , erythema , dystrophy , pathology , hyperkeratosis , pediatrics , short stature
Mal de Meleda (MDM) is a rare autosomal recessive type of palmoplantar keratoderma that is characterized by transgradient keratoderma with scleroatrophy, pseudoainhum around the fingers, and perioral erythema. Its features may also include lichenoid lesions, brachydactyly, and nail dystrophy. The disease has high morbidity and significantly impairs quality of life. Here, we describe two sisters with typical clinical presentations of MDM and a history of consanguinity between the parents.