Open AccessEvaluation of antioxidants in discrete regions of brain after the transplantation of human amniotic epithelial cells in 2,4,5-Trihydroxyphenylethylamine-lesioned wistar albino rats
Author(s) -
Ravisankar Periyasamy,
Panneerselvam Ravishankar,
Elumalai Prithviraj,
Ramesh Rajan
Publication year - 2022
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_692_21
Subject(s) - neurotoxicity , substantia nigra , striatum , transplantation , neurodegeneration , lipid peroxidation , oxidative stress , pharmacology , neurotrophic factors , neuroprotection , endocrinology , chemistry , medicine , parkinson's disease , dopamine , toxicity , disease , receptor
Parkinson's disease (PD) a neurodegenerative disorder for which no preventive or long term effective treatment strategies are available. Epidemiological studies have failed to identify specific environmental, dietary or lifestyle factors for PD. However oxidative stress in the substantia nigra (SN) and Corpus striatum is the most broadly accepted hypothesis for the etiopathology of PD. Many experiments state the notion that augmentation of neurotrophic factors and glial cell-derived neurotrophic factors, could prevent or halt the progress of neurodegeneration in PD.