Open AccessIntradermal Immunization with Heat-Killed Klebsiella pneumoniae Leading to the Production of Protective Immunoglobulin G in BALB/c Mice
Author(s) -
Zannat Kawser,
SM Shamsuzzaman
Publication year - 2021
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_63_20
Subject(s) - antibody , immunization , klebsiella pneumoniae , immunology , medicine , microbiology and biotechnology , antigen , immunoglobulin g , immune system , biology , biochemistry , escherichia coli , gene
Klebsiella pneumoniae superbug is emerging as a serious health concern as resistance to last-resort antibiotics spreads. To bypass the therapeutic molecules used today, the development of an immunoprophylactic safe approach is of great clinical relevance. This study was conducted to determine the protective efficacy of antibodies elicited by killed vaccine against multidrug-resistant (MDR) K. pneumoniae .