Open AccessEvaluation of genetic polymorphisms in glutathione S-Transferase theta1, glutathione S-Transferase mu1, and glutathione S-Transferase mu3 in oral leukoplakia and oral squamous cell carcinoma with deleterious habits using polymerase chain reaction
Author(s) -
Ayyagari Kameswara Rao,
Peela Parameswar,
Swapan Majumdar,
Divya Uppala,
Sreekanth Kotina,
Naga Himabindu Vennamaneni
Publication year - 2017
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_58_16
Subject(s) - glutathione s transferase , chewing tobacco , gstp1 , odds ratio , polymerase chain reaction , genotype , leukoplakia , glutathione , medicine , population , gastroenterology , oncology , biology , cancer , genetics , gene , enzyme , biochemistry , environmental health
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. As per previous studies, most patients who develop oral cancer are elderly males who are heavy users of tobacco and alcohol; however, the incidence is increasing in younger individuals and in those who neither smoke nor drink. Many of the genes that code for the detoxification enzymes are polymorphic with abnormal activity profiles.