Open AccessExpression of human papillomavirus dna and p53 polymorphisms through polymerase chain reaction in normal mucosa and oral leukoplakia individuals with deleterious oral habits
Author(s) -
A. Ramya,
Swapan Majumdar,
Tadakamadla Mahesh Babu,
Divya Uppala,
Baratam Srinivas,
Ayyagari Kameswara Rao
Publication year - 2017
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_57_16
Subject(s) - genotype , polymerase chain reaction , leukoplakia , etiology , oral mucosa , hpv infection , malignant transformation , biology , odds ratio , allele , oral leukoplakia , immunology , medicine , gastroenterology , pathology , cancer research , genetics , gene , cancer , cervical cancer
Oral leukoplakia (OL) is a well-recognized precancerous lesion with various etiological factors. Most commonly deleterious oral habits such as tobacco smoking and viral etiologies mainly human papillomavirus (HPV) play an important role. p53 polymorphisms mostly homozygous Arginine (Arg) allele has a greater risk of degradation by HPV. Hence, HPV infection and p53 polymorphisms may act as synergistic factors for increased the risk of malignant transformation in oral precancerous lesions.