Open AccessSepsis in a 4-month-old boy due to carbapenem-resistant Enterobacteriaceae characterized by AmpC β-lactamase with porin loss
Author(s) -
Junji Shimizu,
Takashi Taga,
Tomomi Satō,
Yawara Eguchi
Publication year - 2018
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_383_17
Subject(s) - enterobacteriaceae , carbapenem resistant enterobacteriaceae , sepsis , septic shock , medicine , incidence (geometry) , resuscitation , porin , carbapenem , antibiotics , microbiology and biotechnology , intensive care medicine , biology , surgery , bacterial outer membrane , escherichia coli , biochemistry , physics , optics , gene
The incidence of carbapenem-resistant Enterobacteriaceae (CRE) infections is increasing, and these infections are associated with both morbidity and mortality. However, little is known about CRE infections in children. This article is a case report describing a 4-month-old boy with Langerhans histiocytosis who developed septic shock due to a CRE infection. The mechanism of carbapenem resistance was identified as AmpC β-lactamase hyperproduction with porin loss. The patient was treated with antibiotics, volume resuscitation, and vasopressors; however, he died of multiorgan failure due to CRE infection. Clinicians should be aware of the prevalence of CRE and the importance of prevention strategies against infection with multidrug-resistant bacteria, even in pediatric populations.