Open AccessEvaluation of leptin as a marker of insulin resistance in type 2 diabetes mellitus
Author(s) -
Thiyagarajan Manjuladevi Moonishaa,
Saurav Narayan Nanda,
Muthukrishnan Shamraj,
Rajendran Sivaa,
Sivakumar Periyasamy,
K. Ravichandran
Publication year - 2017
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_278_16
Subject(s) - leptin , insulin resistance , medicine , adipokine , endocrinology , type 2 diabetes mellitus , insulin , type 2 diabetes , diabetes mellitus , body mass index , obesity , population , homeostatic model assessment , environmental health
Type 2 diabetes mellitus (T2DM) is a leading cause of mortality and morbidity worldwide, whose incidence is rapidly increasing in India. T2DM is caused by varying degrees of insulin resistance (IR) and relative insulin deficiency. Leptin, an adipokine with the primary function of regulating energy balance, is found to mediate insulin secretion and sensitivity in peripheral tissues. Hence, we aimed to determine the role of leptin in the development of IR in newly diagnosed T2DM patients.