Open Accessp53 codon 72 gene polymorphism studies and p53 expression by immunohistochemistry in oral lesions as risk factor for malignancy
Author(s) -
Nishi Tandon,
Anand Srivastava,
Nosheen Fatima,
Syed Tasleem Raza,
Vijay Kumar
Publication year - 2017
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_205_16
Subject(s) - immunohistochemistry , genotype , malignancy , biology , leukoplakia , polymerase chain reaction , pathology , gene , tumor suppressor gene , cancer , medicine , carcinogenesis , genetics
Wild-type p53 nuclear phosphoproteins are critical cell cycle regulatory tumor-suppressor gene. Genetic mutation of p53 gene is common in several head-neck cancers, usually associated with smoking and human papillomavirus (HPV) infection. In India, instead of HPV, tobacco/pan masala chewing is more commonly associated with oral cancer.