Open AccessMolecular detection of fusion oncogenes in zambian patients with acute lymphoblastic leukemia
Author(s) -
Pauline Okuku,
Geoffrey Kwenda,
Mulemba Tillika Samutela,
Panji Nkhoma,
Hamakwa Mantina
Publication year - 2020
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_179_19
Subject(s) - white blood cell , medicine , fusion gene , population , immunology , anemia , leukemia , gastroenterology , oncology , pediatrics , biology , gene , genetics , environmental health
Chromosomal aberrations play a significant role in the pathogenesis of acute lymphoblastic leukemia (ALL) with prognostic and therapeutic implications. Despite the availability of molecular tools, low-resource settings struggle to diagnose the disease due to limited diagnostic capacity. The objective of this study was to detect common chromosomal aberrations in patients with ALL attending the University Teaching Hospital (UTH) in Lusaka, Zambia.