Open AccessInhibition of spontaneous contractility of isolated caprine ureter by flupirtine
Author(s) -
Girish S. Naik,
Rohit Kodagali,
Manoj Tyagi,
K Ernest,
M. Shanthi,
Sumith K Mathew,
Jacob Peedicayil
Publication year - 2018
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_159_17
Subject(s) - contractility , ureter , chemistry , pharmacology , medicine , urology
Kv7 potassium channels are expressed in several types of smooth muscles and could mediate physiological responses in the tissues expressed. Flupirtine is an analgesic that acts by opening Kv7 potassium channels. It has been shown to inhibit the contractility of several types of isolated smooth muscle.