Open AccessA comparative evaluation on the effect of oral zinc 50 mg with or without 0.1% triamcinolone orabase on oral lichen planus
Author(s) -
Chintada Suvarna,
Nallan Csk Chaitanya,
Shaik Ameer,
Himabindu Mannava,
Parinita Bontala,
Jabar Sadan Alyami,
Humaira Samreen,
Jayasurya Kondapaneni
Publication year - 2020
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_138_19
Subject(s) - oral lichen planus , triamcinolone acetonide , medicine , visual analogue scale , gastroenterology , burning sensation , mucous membrane , surgery , dermatology , pathology
Lichen planus is a T-cell-mediated autoimmune disease, in which CD8+ T-cells releases the cytokines such as tumor necrosis factor-alpha and interleukin-12 disrupting basement membrane integrity. Treatment modalities were directed toward the relief in signs and symptoms and preventing recurrences. Zinc activates caspase-3 and DNA fragmentation, resulting in the apoptosis of keratinocytes. Prevention of matrix metalloproteinases1 (MMP1) activation, inhibits the Tcell accumulation in oral lichen planus (OLP) and by inhibiting MMP9, prevents the cleavage of collagen resulting in maintaining the integrity of the basement membrane.