Open AccessHomeostatic Model Assessment of Insulin Activity and Iron Profile among Regular Blood Donors at a Tertiary Health Centre, South-West Nigeria
Author(s) -
Waliu Olatunbosun Oladosu,
Akpojumayenrenne Lawretta Onwah,
Rashidat Oluwatosin Oladosu-Olayiwola,
Abdullahi Ahmed,
M.O. Osinubi,
Olabisi Abosede Gbotosho,
AB Okesina
Publication year - 2020
Publication title -
international journal of applied and basic medical research/international journal of applied and basic medical research
Language(s) - English
Resource type - Journals
eISSN - 2248-9606
pISSN - 2229-516X
DOI - 10.4103/ijabmr.ijabmr_118_19
Subject(s) - total iron binding capacity , ferritin , insulin resistance , glycemic , medicine , homeostatic model assessment , serum iron , transferrin , endocrinology , hemoglobin , insulin , diabetes mellitus , gastroenterology
Iron overload has been established to play a role in the etiopathogenesis of Type 2 diabetes mellitus (DM) as evidenced by its high prevalence among patients with hemochromatosis and transfusion-dependent diseases. This is as a result of iron redox reaction which generates free radicals that cause peroxidation of lipid-rich pancreas, leading to reduced insulin sensitivity.