Open AccessMeasurement of bupivacaine induced myotoxicity in interfascial plane blocks: A randomised controlled trial
Author(s) -
Sonali Kaushal,
Vasundhara Rakhi,
Surinder Singh
Publication year - 2021
Publication title -
indian journal of anaesthesia/indian journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 30
eISSN - 0976-2817
pISSN - 0019-5049
DOI - 10.4103/ija.ija_848_21
Subject(s) - medicine , bupivacaine , anesthesia , myotoxin , creatine kinase , nerve block , randomized controlled trial , surgery , phospholipase a2 , biochemistry , chemistry , enzyme
Recent reports of local-anaesthetic induced myotoxicity after peripheral nerve blocks have increased interest in this less commonly known complication. Although the morphological, physiological and biochemical changes in muscle after injection of clinically used concentration of bupivacaine have been studied in animals, little research has been conducted on human subjects, especially in relation to fascial plane blocks. We conducted a study to examine the changes in circulating creatine phosphokinase (CPK) levels in patients undergoing modified radical mastectomy (MRM) or mesh hernioplasty (MH) with or without peripheral nerve blocks. The study explored local anaesthetic (bupivacaine) induced myotoxicity by measuring changes in serum CPK levels following transversus abdominis plane block (TAP) or pectoral nerve block-II (PEC- II) in patients undergoing MH or MRM, respectively.