Open AccessAn exuberant case of necrobiotic xanthogranuloma
Author(s) -
Sofia Lopes,
Nuno Gomes,
Artúr César,
Ana Margarida Barros,
Jorge Pinheiro,
Filomena Azevedo
Publication year - 2020
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/idoj.idoj_74_19
Subject(s) - medicine , necrobiosis lipoidica , granuloma annulare , monoclonal gammopathy , trunk , differential diagnosis , dermatology , biopsy , granulomatous disease , pathology , sarcoidosis , monoclonal , monoclonal antibody , diabetes mellitus , ecology , antibody , immunology , biology , endocrinology
Necrobiotic xanthogranuloma (NXG) is a rare form of inflammatory granulomatous disease of the skin characterized by the presence of pruritic to painful lesions, generally located in the periorbital area, although trunk and proximal extremities may also be involved. We report a case of a 69-year-old male patient with extensive involvement of the trunk, upper and lower extremities, and an associated gamma monoclonal gammopathy. The skin biopsy was consistent with the diagnosis of NXG. Necrobiosis lipoidica and granuloma annulare were the major differential diagnosis in this case. We highlight the importance of searching for clinical and histological features that may differentiate these entities, which is crucial to select an adequate therapeutic and surveillance strategy.