Open AccessAssessment of the Possible Role of FOXP3 Gene (rs3761548) Polymorphism in Psoriasis Vulgaris Susceptibility and Pathogenesis: Egyptian Study
Author(s) -
Magdy Abdelmageed Elsohafy,
Ashraf Antar Elghzaly,
Hebatallah Mansour Abdelsalam,
Mohammad A. Gaballah
Publication year - 2019
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/idoj.idoj_372_18
Subject(s) - psoriasis , pathogenesis , foxp3 , medicine , genotype , immunology , gene polymorphism , psoriasis area and severity index , allele , family history , gene , genetics , biology , immune system
Psoriasis is an autoimmune-related chronic inflammatory skin disorder. Psoriasis vulgaris (PV) is the most common form of psoriasis. T regulatory cells (Tregs) are typically considered inhibitors of autoimmune responses. FOXP3 is a master control transcription factor for development and function of Tregs. FOXP3 gene polymorphism changes FOXP3 protein function and quantity leading to Tregs dysfunction that subsequently may be related to PV pathogenesis.