Open AccessIdentification of genotypes and allelic frequencies of vitamin D receptor gene polymorphism (TaqI) in egyptian melasma patients
Author(s) -
Iman Seleit,
Ola Ahmed Bakry,
Eman Masoud,
Shaimaa Nabil
Publication year - 2017
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/idoj.idoj_363_16
Subject(s) - taqi , melasma , medicine , genotype , polymorphism (computer science) , allele , allele frequency , genetics , gene , gene polymorphism , calcitriol receptor , dermatology , receptor , biology
Melasma is a characteristic pattern of facial hyperpigmentation, occurring primarily on the forehead, cheeks, and chin, in a mask-like distribution. The pathogenesis of melasma is not fully understood. Vitamin D plays a role in skin pigmentation. It exerts its effect through vitamin D receptor (VDR), which is expressed in variable cells including normal melanocytes.