Open AccessComparison of direct immunofluorescence of plucked hair and skin for evaluation of immunological remission in pemphigus
Author(s) -
Reena Rai,
Manu Vidhya Harikumar
Publication year - 2017
Publication title -
indian dermatology online journal
Language(s) - English
Resource type - Journals
eISSN - 2249-5673
pISSN - 2229-5178
DOI - 10.4103/idoj.idoj_280_16
Subject(s) - pemphigus , medicine , pemphigus vulgaris , autoantibody , dermatology , direct fluorescent antibody , pathology , antibody , immunology
Pemphigus is a chronic autoimmune bullous disorder characterized by autoantibodies directed against desmoglein 3 and/or 1. Demonstration of intercellular deposition of IgG on the cell surface of keratinocytes by direct immunofluorescence (DIF) of the skin is the gold standard in the diagnosis of pemphigus. Recently, DIF of plucked hair demonstrating intercellular deposition of IgG in the outer root sheath (ORS) has shown to be useful.