Open AccessDoes brain natriuretic peptide have a significant diagnostic value in subclinical peripheral atrial disease type 2 diabetic patients?
Author(s) -
Eman M. Fahmy,
Ahmed Saleh Mahdi,
Marwa Gaber,
Mohamed Al Saeed
Publication year - 2017
Publication title -
the egyptian journal of internal medicine/the egyptian journal of internal medicine
Language(s) - English
Resource type - Journals
eISSN - 2090-9098
pISSN - 1110-7782
DOI - 10.4103/ejim.ejim_58_17
Subject(s) - medicine , cardiology , subclinical infection , diabetes mellitus , glycated hemoglobin , retinopathy , brain natriuretic peptide , nephropathy , natriuretic peptide , type 2 diabetes , type 2 diabetes mellitus , creatinine , biomarker , gastroenterology , heart failure , endocrinology , biochemistry , chemistry
Background Peripheral arterial disease (PAD) is a serious complication of diabetes mellitus (DM); it is also correlated with increase in the morbidity and mortality in diabetics owing to cardiovascular disease. Ankle–brachial index (ABI) is an established method to detect PAD.Patients and methods This is a cross-sectional study to detect brain natriuretic peptide (BNP) level in patient with type-2 DM with PAD using ABI.Results This study revealed 11 patients diagnosed with low ABI. Patients with low ABI showed statistical significance regarding mean age (P=0.038), duration of DM (P=0.004), concentration of glycated hemoglobin (P=0.044), BNP (P=0.013), and microalbuminurea (P=0.007). Moreover, patients with low ABI were significantly associated with nephropathy (P=0.001) and retinopathy (P=0.007). BNP at cutoff value of 360 pg/ml had sensitivity and specificity of 27.27 and 95.9, respectively. The BNP level was negatively correlated with the ABI (r=−0.183, P=0.162). BNP showed statistical significance with fasting blood sugar, postprandial glucose, nephropathy, retinopathy, and albumin/creatinine ratio in urine.Conclusion BNP is a potential and a promising biomarker for PAD screening in patients with type-2 DM