Scopoletin and Umbelliferone from Cortex Mori as Protective Agents in High Glucose-Induced Mesangial Cell as in vitro Model of Diabetic Glomerulosclerosis | Zendy

Yijun Liang | Zendy; Xuxin Zeng | Zendy; Jialiang Guo | Zendy; Hui Liu | Zendy; Bao He | Zendy; Renyu Lai | Zendy; Quan Zhu | Zendy; Zhaoguang Zheng | Zendy

Open Access

Scopoletin and Umbelliferone from Cortex Mori as Protective Agents in High Glucose-Induced Mesangial Cell as in vitro Model of Diabetic Glomerulosclerosis

Author(s) -

Yijun Liang,

Xuxin Zeng,

Jialiang Guo,

Hui Liu,

Bao He,

Renyu Lai,

Quan Zhu,

Zhaoguang Zheng

Publication year - 2021

Publication title -

the chinese journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.396

H-Index - 31

eISSN - 2666-0059

pISSN - 0304-4920

DOI - 10.4103/cjp.cjp_9_21

Subject(s) - ctgf , glomerulosclerosis , fibronectin , scopoletin , extracellular matrix , growth factor , mesangial cell , fibrosis , chemistry , transforming growth factor , endocrinology , medicine , microbiology and biotechnology , renal hypertrophy , cell growth , connective tissue , biology , kidney , biochemistry , pathology , diabetic nephropathy , receptor , alternative medicine , proteinuria

Two known coumarins, scopoletin (SP) and umbelliferone (UB), were isolated from Cortex Mori (CM). Their structures were elucidated by various spectroscopic analyses. Then, their effects on rat glomerular mesangial cells (RGMCs, HBZY-1) proliferation, hypertrophy, extracellular matrix (ECM) proliferation, expression of fibronectin, transforming growth factor-beta (TGF-β), and connective tissue growth factor (CTGF) induced by high glucose were studied in vitro model of diabetic glomerulosclerosis. The results show that, CM, SP, and UB can inhibit the RGMCs proliferation to attenuate the ECM proliferation and cell hypertrophy, reduced the accumulation of ECM protein fibronectin, and lowered the expression of the key fibrosis factor TGF-β and CTGF to inhibit the kidney fibrosis and thereby improved diabetic glomerulosclerosis. The two coumarins show great potentialities on treating diabetic glomerulosclerosis, but the animal experiment and mechanism is strongly needed for further proof.

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