Long-Term Aerobic Exercise Training-Induced Anti-Inflammatory Response and Mechanisms | Zendy

Chien-Wei Chen | Zendy; YuChi Kuo | Zendy; ChorngKuang How | Zendy; ChiChang Juan | Zendy

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Long-Term Aerobic Exercise Training-Induced Anti-Inflammatory Response and Mechanisms

Author(s) -

Chien-Wei Chen,

YuChi Kuo,

ChorngKuang How,

ChiChang Juan

Publication year - 2020

Publication title -

the chinese journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.396

H-Index - 31

eISSN - 2666-0059

pISSN - 0304-4920

DOI - 10.4103/cjp.cjp_78_20

Subject(s) - aerobic exercise , immune system , inflammation , training (meteorology) , receptor , pi3k/akt/mtor pathway , toll like receptor , medicine , protein kinase b , immunology , signal transduction , biology , innate immune system , microbiology and biotechnology , physics , meteorology

Toll-like receptor 4 (TLR-4), which regulate inflammatory reactions, has become a popular research topic in recent years. This article reviews the latest scientific evidence on the regulation of TLR-4 by regular aerobic exercise training. The literature shows that long-term regular aerobic exercise training can effectively attenuate the expression of TLR-4 in immune cells and regulate its downstream intracellular cascade, including the p38 and PI3K/Akt signaling pathways. This further reduces cytokines secretion by inflammatory cells, which enhances immune system. We consider that the scientific evidence that long-term aerobic exercise training improves the inflammatory response provides a reasonable basis for using aerobic exercise training as a treatment for patients.

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