Open AccessPulmonary arterial hypertension and flavonoids: A role in treatment
Author(s) -
Jialing Wang,
Hailong Li,
Tian Xia,
Jun Feng,
Ran Zhou
Publication year - 2021
Publication title -
chinese journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.396
H-Index - 31
eISSN - 2666-0059
pISSN - 0304-4920
DOI - 10.4103/cjp.cjp_25_21
Subject(s) - medicine , pulmonary hypertension , intensive care medicine , pharmacodynamics , mechanism (biology) , pulmonary disease , disease , pharmacology , bioinformatics , cardiology , biology , pharmacokinetics , philosophy , epistemology
Pulmonary arterial hypertension (PAH) is a high mortality progressive pulmonary vascular disease that can lead to right heart failure. The use of clinical drugs for the treatment of PAH is limited to a great extent because of its single target and high price. Flavonoids are widely distributed in nature, and have been found in fruits, vegetables, and traditional Chinese medicine. They have diverse biological activities and various pharmacological effects such as antitumor, antioxidation, and anti-inflammatory. This review summarizes the progress in pharmacodynamics and mechanism of flavonoids in the treatment of PAH in recent years, in order to provide some theoretical references for relevant researchers.