Pulmonary Arterial Hypertension and Flavonoids | Zendy

Jialing Wang | Zendy; Hailong Li | Zendy; Tian Xia | Zendy; Jun Feng | Zendy; Ru Zhou | Zendy

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Pulmonary Arterial Hypertension and Flavonoids

Author(s) -

Jialing Wang,

Hailong Li,

Tian Xia,

Jun Feng,

Ru Zhou

Publication year - 2021

Publication title -

the chinese journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.396

H-Index - 31

eISSN - 2666-0059

pISSN - 0304-4920

DOI - 10.4103/cjp.cjp_25_21

Subject(s) - medicine , pulmonary hypertension , pharmacodynamics , right heart failure , intensive care medicine , mechanism (biology) , disease , pulmonary disease , cardiology , pharmacology , pharmacokinetics , philosophy , epistemology

Pulmonary arterial hypertension (PAH) is a high mortality progressive pulmonary vascular disease that can lead to right heart failure. The use of clinical drugs for the treatment of PAH is limited to a great extent because of its single target and high price. Flavonoids are widely distributed in nature, and have been found in fruits, vegetables, and traditional Chinese medicine. They have diverse biological activities and various pharmacological effects such as antitumor, antioxidation, and anti-inflammatory. This review summarizes the progress in pharmacodynamics and mechanism of flavonoids in the treatment of PAH in recent years, in order to provide some theoretical references for relevant researchers.

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