Open AccessGenotoxic effects of silver amalgam and composite restorations: Micronuclei-Based cohort and case–control study in oral exfoliated cells
Author(s) -
S Jeslin Mary,
K L Girish,
T Isaac Joseph,
Pradeesh Sathyan
Publication year - 2018
Publication title -
contemporary clinical dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 21
eISSN - 0976-237X
pISSN - 0976-2361
DOI - 10.4103/ccd.ccd_849_17
Subject(s) - amalgam (chemistry) , dentistry , micronucleus test , medicine , buccal administration , dental composite , molar , context (archaeology) , dental restoration , composite number , materials science , chemistry , toxicity , biology , electrode , paleontology , composite material
A huge number of people carry dental fillings which contain either mercury-based amalgam and/or the recently introduced methacrylate-based resins. It has been shown that both these materials are known to be leached into the oral cavity and induce genotoxic alterations in the buccal mucosal cells. Because of its low cost and ease of manipulation, dental amalgam is still widely used as a restorative material in developing countries. The health risks associated with the components of this restorative material has always been a matter of concern. The present study was designed to assess the frequency of micronuclei (MN) in oral mucosal cells as it is a promising tool for studying the genotoxic effect of clastogenic agents on them.