Open AccessThe effect of combination spirulina–chitosan on angiogenesis, osteoclast, and osteoblast cells in socket models of hyperglycemic Rattus norvegicus
Author(s) -
Nike Hendrijantini,
Rostiny Rostiny,
Mefina Kuntjoro,
Kent Sidharta,
Dea Syarafina Putri Wiyono,
Alocitta Anindyanari,
Sherman Salim
Publication year - 2018
Publication title -
contemporary clinical dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 21
eISSN - 0976-237X
pISSN - 0976-2361
DOI - 10.4103/ccd.ccd_617_18
Subject(s) - osteoclast , osteoblast , angiogenesis , bone resorption , resorption , bone healing , bone formation , medicine , chitosan , endocrinology , chemistry , dentistry , andrology , biochemistry , anatomy , in vitro , receptor
Prolongation of the inflammatory process in hyperglycemic interferes with bone formation, inhibits the healing process, and triggers bone resorption. A combination of spirulina and chitosan in the tooth socket of Rattus norvegicus is expected to promote the bone remodeling process. This study aimed to evaluate the effect of spirulina and chitosan on angiogenesis, osteoclast, and osteoblast cell in tooth socket models of type 1 diabetes.