Open AccessTransposition of the great arteries: A laterality defect in the group of heterotaxy syndromes or an outflow tract malformation?
Author(s) -
Rana S Al-Zahrani,
Samaher H Alharbi,
Rawan M A Tuwaijri,
Bayan T Alzomaili,
Alaa Althubaiti,
T. Mesud Yelbuz
Publication year - 2018
Publication title -
annals of pediatric cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.292
H-Index - 19
eISSN - 0974-2069
pISSN - 0974-5149
DOI - 10.4103/apc.apc_24_18
Subject(s) - great arteries , medicine , heterotaxy , laterality , transposition (logic) , cardiology , radiology , heart disease , audiology , linguistics , philosophy
Transposition of the great arteries (TGA) is traditionally classified as a "conotruncal heart defect", implying that TGA evolves from abnormal development of the outflow tract (OFT) of the embryonic heart. However, recently published genetic data suggest that TGA may be linked to laterality gene defects rather than OFT gene defects. The aim of our study was to clarify whether there is any statistically significant link between TGA and clinically diagnosed laterality defects (heterotaxy).