Open AccessAdding further evidence for clinically significant anti-Leb antibody in a voluntary blood donor
Author(s) -
Gita Negi,
Sheetal Malhotra,
Sushant Kumar Meinia,
Daljit Kaur,
Divya Rai
Publication year - 2020
Publication title -
asian journal of transfusion science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/ajts.ajts_68_19
Subject(s) - medicine , blood donor , antibody , donation , blood group antigens , transfusion reaction , blood transfusion , fresh frozen plasma , whole blood , immunology , platelet , economics , economic growth
Herein, we report a case of naturally occurring anti-Le b alloantibody identified in the plasma of a first time voluntary blood donor. The immunohematology workup was done on the pilot sample tubes collected during blood donation by the conventional tube technique and using ID-Micro Column System Glass Beads card (anti-IgG, C 3 d; Ortho-Clinical Diagnostics, Raritan, New Jersey, USA). Blood group of the donor was confirmed to be B RhD positive, and the alloantibody in his plasma was identified as anti-Le b , having clinically significant characteristics. Since in this particular case, anti-Le b was IgM and IgG in nature, it was clinically significant and can lead to hemolytic transfusion reaction, especially if such fresh frozen plasma unit is transfused to Le b negative patients.