Open AccessManual red cell exchange transfusion to avert sickle cell related complications
Author(s) -
Ruhi A Mehra,
Shivali Gupta,
D B Borkar
Publication year - 2018
Publication title -
asian journal of transfusion science
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/ajts.ajts_128_16
Subject(s) - medicine , exchange transfusion , avascular necrosis , hematocrit , sickle cell anemia , blood viscosity , red cell , thalassemia , femoral head , cell , surgery , disease , biology , genetics
Sickle cell-beta thalassemia is a double heterozygous state. Red cell exchange (RCE) transfusion reduces the concentration of sickle cells without increasing the hematocrit or whole-blood viscosity. It can be performed manually or by erythrocytapheresis. RCE transfusion is an effective tool for both acute and chronic complications of sickle cell disease. In patients unaffording erythrocytapheresis, even manual RCE can give favorable results. A 37-year-old male, a known case of sickle cell-beta + thalassemia (β s β+), presented with avascular necrosis of right femur and humeral head. He was posted for the right hip arthroplasty and shoulder hemiarthroplasty. Successful manual RCE transfusions were done. The hemoglobin S levels decreased postmanual RCE procedures, and the patient was operated successfully.