Open AccessA rare case of a high-grade astroblastoma with 5-year follow-up
Author(s) -
Lawrence D Cruze,
Sandhya Sundaram,
Shruti Iyer,
Ganga Krishnamurthy
Publication year - 2021
Publication title -
asian journal of neurosurgery
Language(s) - English
Resource type - Journals
ISSN - 2248-9614
DOI - 10.4103/ajns.ajns_315_20
Subject(s) - medicine , pathological , diplopia , radiation therapy , ganglioglioma , pleomorphic xanthoastrocytoma , work up , radiology , surgery , pathology , glioma , astrocytoma , cancer research , psychiatry , epilepsy
Astroblastoma is a very rare glial tumor derived from astroblasts. It has been controversial in terms of its features and diagnosis. The objective of this report is to present the findings of the high-grade astroblastoma with a good prognosis in a 21-year-old female who presented to us with diplopia and headache. While imaging led to the foremost differentials of pleomorphic xanthoastrocytoma and Ganglioglioma which are low-grade neoplasms, the final diagnosis was established on microscopy and immunohistochemistry after excision. Treatment protocol included surgery with postoperative radiotherapy and chemotherapy. Due to controversial and limited literature, this tumor poses difficulties in diagnosis and management. This is a rare, successfully managed case of astroblastoma with a positive outcome 5 years after the diagnosis was established. In this case report, we review the steps of diagnosis, the differentials, the pathological and histological features, and the management of this rare entity.