Open AccessAggressive primary pediatric intracranial malignant melanoma: Sphinx of the tissue diagnosis
Author(s) -
Laxminadh Sivaraju,
Nandita Ghosal,
Anita Mahadevan,
AS Uday Krishna,
Shilpa Rao,
Alangar S. Hegde
Publication year - 2019
Publication title -
asian journal of neurosurgery
Language(s) - English
Resource type - Journals
ISSN - 2248-9614
DOI - 10.4103/ajns.ajns_253_17
Subject(s) - medicine , histopathology , melanoma , differential diagnosis , pathology , lesion , soft tissue , malignant meningioma , meningioma , radiology , cancer research
It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. This case is discussed in light of very uncommon occurrence of intracranial PMM in pediatric age group, enigmatic histological features, and aggressive nature of lesion with rapid progression despite complete excision following radiation therapy.