Open AccessThe roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis
Author(s) -
Yonghong Man,
Isabella Warmbrunn,
Ling Zhang,
Zhibing Zhang
Publication year - 2022
Publication title -
asian journal of andrology/asian journal of andrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.701
H-Index - 74
eISSN - 1745-7262
pISSN - 1008-682X
DOI - 10.4103/aja202179
Subject(s) - intraflagellar transport , cilium , ciliogenesis , microbiology and biotechnology , signal transduction , biology , organelle , ciliopathy , cytoplasm , biogenesis , transport protein , flagellum , biochemistry , gene , phenotype
Cilium, an organelle with a unique proteome and organization, protruding from the cell surface, generally serves as a force generator and signaling compartment. During ciliogenesis, ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport (IFT) particles, where the inner counterparts undergo reverse trafficking. The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction. Much progress has been made on the mechanisms and functions of IFT; however, recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis. In this review, we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.