Open AccessDiagnostic utility of human leukocyte antigen B*15:02 screening in severe carbamazepine hypersensitivity syndrome
Author(s) -
Youssef Moutaouakkil,
Badr Adouani,
Yahia Cherrah,
Jamal Lamsaouri,
Yassir Bousliman
Publication year - 2019
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/aian.aian_492_18
Subject(s) - medicine , carbamazepine , confidence interval , odds ratio , toxic epidermal necrolysis , gastroenterology , receiver operating characteristic , human leukocyte antigen , population , subgroup analysis , immunology , antigen , dermatology , epilepsy , psychiatry , environmental health
Despite many studies suggesting an association between human leukocyte antigen (HLA)-B*15:02 and carbamazepine (CBZ)-induced severe cutaneous adverse drug reactions essentially toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), the evidence of association in different populations and the degree of association remain uncertain.