Open AccessAnti myelin oligodendrocyte glycoprotein associated immunoglobulin G (AntiMOG-IgG)-associated neuromyelitis optica spectrum disorder with persistent disease activity and residual cognitive impairment
Author(s) -
Lekha Pandit,
Ichiro Nakashima,
Sharik Mustafa,
Toshiyuki Takahashi,
Kimhiko Kaneko
Publication year - 2017
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/aian.aian_250_17
Subject(s) - neuromyelitis optica , myelin oligodendrocyte glycoprotein , medicine , optic neuritis , multiple sclerosis , spectrum disorder , immunology , demyelinating disorder , myelitis , optic nerve , acute disseminated encephalomyelitis , oligodendrocyte , disease , immunoglobulin g , pathology , myelin , central nervous system , spinal cord , antibody , experimental autoimmune encephalomyelitis , psychiatry , ophthalmology
Antibodies targeting myelin oligodendrocyte glycoprotein (MOG) have been recently reported in association with idiopathic inflammatory central nervous system disorders. Initially believed to be a benign disorder, anti MOG-IgG was noted to cause steroid responsive recurrent optic neuritis and isolated longitudinally extensive myelitis. However, there is growing evidence that the disease may be predominantly relapsing, often producing severe visual loss and involving regions other than the spinal cord and optic nerve. We report an adolescent male with an aggressive disease course previously undescribed in anti MOG-IgG-associated disease that left him with residual cognitive dysfunction.