Open AccessCutaneous adverse drug reactions to lamotrigine and human leukocyte antigen typing in North Indian patients: A case series
Author(s) -
Shivani Srivastava,
Bhargavi Ramanujam,
Kavish Ihtisham,
Manjari Tripathi
Publication year - 2017
Publication title -
annals of indian academy of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 31
eISSN - 1998-3549
pISSN - 0972-2327
DOI - 10.4103/aian.aian_234_17
Subject(s) - medicine , lamotrigine , carbamazepine , human leukocyte antigen , phenytoin , typing , valproic acid , drug , allele , adverse drug reaction , population , adverse effect , immunology , pharmacology , epilepsy , dermatology , antigen , psychiatry , genetics , biology , gene , environmental health
Cutaneous adverse drug reaction (cADR) has limited epidemiological data in India. The older antiepileptic drugs, i.e., carbamazepine, phenytoin, valproic acid, phenobarbitone, etc., induce severe cADRs that have a strong associated with human leukocyte antigen (HLA)-related genetic risk factors. There is also evidence of association of certain HLA alleles with lamotrigine (LTG)-induced cADRs, but this has not been reported in the Indian population. Here, we report case series of three patients with LTG-induced "Stevens-Johnson syndrome (SJS)." Their HLA-B typing was also performed which showed the presence of HLA-B*15:02 in one case with SJS.