Open AccessFentanyl-induced respiratory depression: A narrative review on the possible single-nucleotide polymorphism
Author(s) -
Prabha Udayakumar,
Srisruthi Udayakumar
Publication year - 2021
Publication title -
al-banǧ. maqālāt wa abḥāṯ fī al-taẖdīr wa-al-in’āš
Language(s) - English
Resource type - Journals
ISSN - 0259-1162
DOI - 10.4103/aer.aer_94_21
Subject(s) - fentanyl , depression (economics) , single nucleotide polymorphism , polymorphism (computer science) , narrative review , medicine , respiratory system , anesthesia , genetics , psychology , psychiatry , biology , gene , intensive care medicine , genotype , economics , macroeconomics
Opioid-related respiratory depression is a serious clinical problem as it can cause multiple deaths and anoxic brain injury. Genetic variations influence the safety and clinical efficacy of fentanyl. Pharmacogenetic studies help in identifying single-nucleotide polymorphisms (SNPs) associated with fentanyl causing respiratory depression and aid clinician in personalized pain medicine. This narrative review gives an insight of the common SNPs associated with fentanyl.