Fentanyl-Induced Respiratory Depression | Zendy

Prabha Udayakumar | Zendy; Srisruthi Udayakumar | Zendy

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Fentanyl-Induced Respiratory Depression

Author(s) -

Prabha Udayakumar,

Srisruthi Udayakumar

Publication year - 2021

Publication title -

anesthesia essays and researches

Language(s) - English

Resource type - Journals

ISSN - 0259-1162

DOI - 10.4103/aer.aer_94_21

Subject(s) - fentanyl , medicine , depression (economics) , pharmacogenetics , single nucleotide polymorphism , anesthesia , respiratory system , opioid , narrative review , respiratory arrest , intensive care medicine , psychiatry , gene , biology , genotype , genetics , receptor , economics , macroeconomics

Opioid-related respiratory depression is a serious clinical problem as it can cause multiple deaths and anoxic brain injury. Genetic variations influence the safety and clinical efficacy of fentanyl. Pharmacogenetic studies help in identifying single-nucleotide polymorphisms (SNPs) associated with fentanyl causing respiratory depression and aid clinician in personalized pain medicine. This narrative review gives an insight of the common SNPs associated with fentanyl.

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