Oral pregabalin as premedication on anxiolysis and stress response to laryngoscopy and endotracheal intubation in patients undergoing laparoscopic cholecystectomy: A randomized double-blind study | Zendy

JaybrijeshSingh Yadav | Zendy; Dheer Singh | Zendy; BirendraKumar Jamuda | Zendy; Pooja Singh | Zendy

Open Access

Oral pregabalin as premedication on anxiolysis and stress response to laryngoscopy and endotracheal intubation in patients undergoing laparoscopic cholecystectomy: A randomized double-blind study

Author(s) -

JaybrijeshSingh Yadav,

Dheer Singh,

BirendraKumar Jamuda,

Pooja Singh

Publication year - 2019

Publication title -

anesthesia essays and researches

Language(s) - English

Resource type - Journals

ISSN - 0259-1162

DOI - 10.4103/aer.aer_12_19

Subject(s) - medicine , anesthesia , pregabalin , laryngoscopy , intubation , premedication , blood pressure , heart rate , placebo , alternative medicine , pathology

Direct laryngoscopy and tracheal intubation lead to increase in heart rate and blood pressure. This can cause serious complications in patients with coronary artery disease, reactive airways, or intracranial neuropathology. Preoperative anxiety is associated with greater level of postoperative pain. Attenuation of anxiety and hemodynamic response to laryngoscopy and intubation are cornerstone of better anesthetic outcome. Gabapentinoids (gabapentin and pregabalin) have been known to possess anxiolytic, analgesic, and anticonvulsant properties.

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