Open AccessComparison of postoperative cognitive decline in patients undergoing conventional vs miniaturized cardiopulmonary bypass: A randomized, controlled trial
Author(s) -
Yuhe Ke,
Sophia Tsong Huey Chew,
An Shing Ang,
Roderica Rui Ge Ng,
Nantawan Boonkiangwong,
Weiling Liu,
Anastasia Han Hao Toh,
Michael George Caleb,
Roger Ho,
Lian Kah Ti
Publication year - 2020
Publication title -
annals of cardiac anaesthesia/annals of cardiac anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.42
H-Index - 27
eISSN - 0974-5181
pISSN - 0971-9784
DOI - 10.4103/aca.aca_192_18
Subject(s) - medicine , cardiopulmonary bypass , postoperative cognitive dysfunction , anesthesia , hematocrit , randomized controlled trial , incidence (geometry) , confidence interval , cognition , physics , psychiatry , optics
Neurocognitive dysfunction is a common complication of coronary artery bypass grafting (CABG) with incidence of 19-38%. The miniaturized cardiopulmonary bypass (MCPB) system was developed to reduce hemodilution and inflammation and provides better cerebral protection than conventional cardiopulmonary bypass (CCPB). In a meta-analysis, MCPB was associated with a 10-fold reduction in the incidence of strokes. However, its effect on postoperative cognitive decline (POCD) is unknown. We assessed if MCPB decreases POCD after CABG and compared the risk factors.