Open AccessThe challenges of lymphoma diagnosis in a Tertiary Hospital in Lagos, Nigeria
Author(s) -
Olakanmi Ralph Akinde,
C C Anunobi,
Oluseye Vincent Osunkalu,
Adekoyejo Abiodun Phillips,
Olatunji Micheal Afolayan
Publication year - 2016
Publication title -
journal of clinical sciences
Language(s) - English
Resource type - Journals
eISSN - 2468-6859
pISSN - 2408-7408
DOI - 10.4103/2408-7408.179679
Subject(s) - medicine , lymphoma , h&e stain , immunohistochemistry , pathology , radiology
Background: In most tertiary centers across sub-Saharan countries, hematoxylin and eosin (H and E) stained slide is the main method of diagnosing lymphomas, and this has been found to be inadequate in diagnostic hematological malignancies. Aim and Objectives: To review the diagnostic utility and limitations of H and E, tissue diagnostic modality of solid hematolymphoid malignancies. Materials and Methods: The diagnosis based on both morphology and immunohistochemistry (IHC) assessments were compared with those based solely on morphology. Results: Of all, the 116 cases of lymphomas, only 32 (27.6%) were correctly diagnosed and subtyped by morphology while 53 (46%) cases were diagnosed to be lymphomas but could not be subtyped by morphology. Nineteen (16.4%) cases were wrongly subtyped. Five cases of reactive lesions were wrongly diagnosed as malignant lymphoma. Conclusion: This study makes a case for the mandatory use of IHC in the diagnosis of suspected cases of lymphomas