Open AccessOral melanocytic nevi: Report of two cases with immunohistochemical elaboration of their probable origin and maturation
Author(s) -
Dipti Dutta,
Venkatesh V Kamath,
Komali Rajkumar
Publication year - 2015
Publication title -
indian journal of dermatopathology and diagnostic dermatology
Language(s) - English
Resource type - Journals
ISSN - 2349-6029
DOI - 10.4103/2349-6029.173413
Subject(s) - melanocytic nevus , pathology , histopathology , nevus , oral mucosa , immunohistochemistry , lesion , dermatology , population , medicine , biology , melanoma , cancer research , environmental health
Oral melanocytic nevi are localized developmental tissue malformations of nevus cells in the oral mucosa. Relatively rare in occurrence compared to their dermal counterparts, considerable debate exists in the literature related to their origin, development and maturation, and their relationship to oral melanocytes.We report two cases of oral melanocytic nevi with classical clinical presentation. The histopathology was consistent with the known patterns of oral melanocytic nevi. Special stains such as Masson Fontana, further substantiated the observation. S-100 and HMB-45 were applied to immunohistochemically elaborate the cell population. Interestingly two distinct cell populations were detected in the lesions. "Type A" cells in the center of the lesion were S-100 positive, indicating a neural origin and immaturity in development, while peripheral "type B" cells stained positive with HMB-45, indicating melanocytic origin and mature development