Open AccessSquamoid eccrine ductal carcinoma: A diagnostic challenge
Author(s) -
Jayashree Krishnamurthy,
Lopa Mudra Kakoti,
Ravishankar Nagaraj
Publication year - 2014
Publication title -
indian journal of dermatopathology and diagnostic dermatology
Language(s) - English
Resource type - Journals
ISSN - 2349-6029
DOI - 10.4103/2349-6029.147313
Subject(s) - cytokeratin , medicine , pathology , scalp , invasive ductal carcinoma , immunohistochemistry , ductal carcinoma , carcinoma , dermis , lesion , dermatology , cancer , breast cancer
Squamoid eccrine ductal carcinoma (SEDC) is a rare primary cutaneous tumor that exhibits both squamous and adnexal ductal differentiation. We report a case of SEDC presenting as multiple nodules on the scalp of a 58-year-old man. Histopathological examination of the excised lesion showed a tumor in the dermis composed of duct-like structures that represented the eccrine component and squamoid cells in nests and in an infiltrating pattern. Immunohistochemical (IHC) positivity for cytokeratin 5/6, epithelial membrane antigen (EMA), and p63 confirmed the squamoid, ductal, and primary cutaneous nature, respectively, and differentiated it from eccrine poroma, microcystic adnexal carcinoma, and porocarcinoma with squamous differentiation. With a demonstrated invasive potential, recurrent nature, and ambiguous metastatic potential, Mohs micrographic surgery, an established and successful, yet tissue-sparing surgical modality with lower recurrence rate, is the recommended treatment of choice and a close follow-up of these patients is suggested for further experiences of this tumor