Open AccessStudy of cognitive profile in the elderly presenting with both depressive and cognitive symptoms
Author(s) -
Shipra Singh,
Sunitha Shanker,
Alka A Subramanyam,
Ravindra Kamath
Publication year - 2015
Publication title -
journal of geriatric mental health
Language(s) - English
Resource type - Journals
eISSN - 2395-3322
pISSN - 2348-9995
DOI - 10.4103/2348-9995.174274
Subject(s) - escitalopram , cognition , context (archaeology) , depression (economics) , major depressive disorder , clinical psychology , mood , psychology , medicine , wilcoxon signed rank test , psychiatry , anxiety , mann–whitney u test , antidepressant , macroeconomics , economics , paleontology , biology
Background: Elderly patients presenting with cognitive and depressive symptoms often create a diagnostic challenge between depression and the dementing process. Various screening and diagnostic instruments have been developed for differentiating the two, one of which is Addenbrooke′s cognitive examination (ACE). However, results have not been consistent across various studies, and not much data is available in the Indian context. Aims and Objectives: To study cognition in elderly patients presenting with both cognitive and depressive symptoms at the baseline and at 3 months follow-up after starting antidepressants, and to compare the two profiles. Materials and Methods: It was a follow-up study with 70 participants who had presented with both depressive and cognitive symptoms. Tablet escitalopram was given and ACE was performed at the baseline and at 3 months after starting antidepressants. Improvement on ACE was present in 37 participants and absent in 33 participants. The cognitive profile of these two groups was subjected to statistical analysis. Wilcoxon signed-rank test was used to study the difference between the full and domain ACE scores between the preintervention phase and postintervention phase within each group. Results: There is a significant difference between preintervention and postintervention full ACE scores and different domain scores in the depression group unlike in the MCI group.Conclusion: Diagnostic tools such as ACE can be utilized for differentiating mood disorder with an actual dementing process. It also reveals the need for periodic assessments of such patients