Open AccessGamma-aminobutyric-acid-B receptor antibodies in limbic encephalitis with small cell lung cancer
Author(s) -
Ke-Qin Liu,
Shengqiang Yan,
Min Lou
Publication year - 2015
Publication title -
neuroimmunolgy and neuroinflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 4
eISSN - 2349-6142
pISSN - 2347-8659
DOI - 10.4103/2347-8659.159077
Subject(s) - medicine , publishing , antibody , lung cancer , receptor , neuroscience , cancer research , immunology , pathology , literature , biology , art
Encephalitis associated with antibodies to gamma-aminobutyric-acid B (GABA-B) is a subgroup of autoimmune synaptic encephalitis with typical features of limbic encephalitis and small cell lung cancer (SCLC). We report a case of anti-GABA-B receptor encephalitis in a 57-year-old man who presented with seizures, memory loss, and abnormal behavior. He developed partially neurological responses to immunotherapy, but refused comprehensive tumor screening. The symptoms were aggravated again 4 months later. Workup showed antibodies to GABA-B receptors and tumor screening revealed SCLC. It highlights the importance of early screening of underlying tumor and anti-tumor treatment in paraneoplastic cases