Gamma-aminobutyric-acid-B receptor antibodies in limbic encephalitis with small cell lung cancer | Zendy

Min Lou | Zendy; Keqin Liu | Zendy; Sheng-Qiang Yan | Zendy

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Gamma-aminobutyric-acid-B receptor antibodies in limbic encephalitis with small cell lung cancer

Author(s) -

Min Lou,

Keqin Liu,

Sheng-Qiang Yan

Publication year - 2015

Publication title -

neuroimmunology and neuroinflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.125

H-Index - 4

eISSN - 2349-6142

pISSN - 2347-8659

DOI - 10.4103/2347-8659.159077

Subject(s) - medicine , publishing , antibody , lung cancer , receptor , neuroscience , cancer research , immunology , pathology , literature , biology , art

Encephalitis associated with antibodies to gamma-aminobutyric-acid B (GABA-B) is a subgroup of autoimmune synaptic encephalitis with typical features of limbic encephalitis and small cell lung cancer (SCLC). We report a case of anti-GABA-B receptor encephalitis in a 57-year-old man who presented with seizures, memory loss, and abnormal behavior. He developed partially neurological responses to immunotherapy, but refused comprehensive tumor screening. The symptoms were aggravated again 4 months later. Workup showed antibodies to GABA-B receptors and tumor screening revealed SCLC. It highlights the importance of early screening of underlying tumor and anti-tumor treatment in paraneoplastic cases

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