Open AccessCerebral aneurysms and inflammation
Author(s) -
Toshihiro Yokoi,
Makoto Saito,
Yayoi Yoshimura,
Keiichi Tsuji,
Kazuhiko Nozaki
Publication year - 2015
Publication title -
neuroimmunolgy and neuroinflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 4
eISSN - 2349-6142
pISSN - 2347-8659
DOI - 10.4103/2347-8659.153977
Subject(s) - medicine , publishing , medical education , literature , art
Multiple inflammatory factors, playing a crucial role in cerebral aneurysm formation, have been identified. tumor necrosis factor-alpha (TNF-α) has been revealed to have a close connection with several risk factors that affect aneurysm formation. Remarkable expression in aneurysm walls of mRNA for TNF-α has been observed in humans. Possible therapeutic interventions to reduce the formation of cerebral aneurysms may include the inhibition of mediators of inflammation