Open AccessAnti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice
Author(s) -
Anu Elizabeth Joy,
Shankar Bhat Kunhikatta,
Shyamjith Manikkoth
Publication year - 2013
Publication title -
archives of medicine and health sciences
Language(s) - English
Resource type - Journals
eISSN - 2321-6085
pISSN - 2321-4848
DOI - 10.4103/2321-4848.113548
Subject(s) - convulsant , convulsion , moringa , medicine , hindlimb , tonic (physiology) , pharmacology , traditional medicine , pentylenetetrazol , anticonvulsant , epilepsy , receptor , psychiatry
Objectives : To investigate the anti-convulsant activity of ethanolic extract of Moringa concanensis leaves on maximal electroshock-induced seizures (MES) and pentylenetetrazole (PTZ)-induced seizures in Swiss albino mice. Materials and Methods : The ethanolic extract of Moringa concanensis leaves (200 mg/kg, i.p) was studied for its anti-convulsant effect on MES and PTZ-induced seizures in Swiss albino mice. In MES seizures, suppression of tonic hind limb extension was noted. In PTZ seizures, abolition of the convulsions was noted. Results : The ethanolic extract of the leaves of Moringa concanensis (200 mg/kg, i.p) significantly (P < 0.001) abolished the hind limb extension induced by MES. The same dose also significantly (P < 0.001) protected the animals from PTZ-induced tonic convulsions. Conclusion : The data suggests that the ethanolic extract of Moringa concanensis leaves may produce its anti-convulsant effects via multiple mechanisms since it abolished the hind limb extension induced by MES as well as abolished seizures produced by PTZ