Open AccessDapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management
Author(s) -
Kamal Kumar Sawlani,
Shyam Chand Chaudhary,
Jitendra Singh,
Deep Chandh Raja,
Sanjay Kumar Mishra,
Madhu Mati Goel
Publication year - 2016
Publication title -
journal of research in pharmacy practice
Language(s) - English
Resource type - Journals
eISSN - 2319-9644
pISSN - 2279-042X
DOI - 10.4103/2279-042x.185743
Subject(s) - dapsone , medicine , dermatitis herpetiformis , dermatology , jaundice , pure red cell aplasia , toxicity , gastroenterology , immunology , bone marrow , disease
Dapsone (4,4'- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis. Patient had an excellent response to corticosteroids after withdrawal of dapsone.