Open AccessPredictive performance of Vancomycin population pharmacokinetic models in Iranian patients underwent hematopoietic stem cell transplantation
Author(s) -
Maryam Taghizadeh-Ghehi,
Saeed Rezaee,
Kheirollah Gholami,
Molouk Hadjibabaie
Publication year - 2015
Publication title -
journal of research in pharmacy practice
Language(s) - English
Resource type - Journals
eISSN - 2319-9644
pISSN - 2279-042X
DOI - 10.4103/2279-042x.162357
Subject(s) - medicine , vancomycin , pharmacokinetics , hematopoietic stem cell transplantation , neutropenia , confidence interval , population , dosing , trough concentration , transplantation , surgery , toxicity , biology , environmental health , bacteria , genetics , staphylococcus aureus
Many hematopoietic stem cell transplantation (HSCT) patients receive vancomycin empirically during febrile neutropenia. There are several models for estimation of vancomycin pharmacokinetic parameters and calculation of initial dosing regimen accordingly. However, the performance of these methods in HSCT patients remained to be evaluated. The aim of the study was to determine which of the vancomycin population pharmacokinetic methods best fit Iranian HSCT patients.