Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris? | Zendy

Nabet Tajmirriahi | Zendy; Fariba Iraji | Zendy; Iman Momeni | Zendy; Kioumars Jamshidi | Zendy; Fazlollah Hashemzehi | Zendy; Amir Hossein Siadat | Zendy; AlirezaAsemi Esfahani | Zendy

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Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?

Author(s) -

Nabet Tajmirriahi,

Fariba Iraji,

Iman Momeni,

Kioumars Jamshidi,

Fazlollah Hashemzehi,

Amir Hossein Siadat,

AlirezaAsemi Esfahani

Publication year - 2016

Publication title -

advanced biomedical research

Language(s) - English

Resource type - Journals

ISSN - 2277-9175

DOI - 10.4103/2277-9175.191002

Subject(s) - pemphigus vulgaris , desmoglein 3 , desmoglein 1 , prolactin , pemphigus , medicine , pathogenesis , desmoglein , antibody , immunology , autoantibody , hormone

Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris.Materials and Methods: Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris.Results: There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02, P = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09, P = 0.38).Conclusion: This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris

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