Open AccessDo serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?
Author(s) -
Fariba Iraji,
Nabet Tajmirriahi,
Iman Momeni,
Kioumars Jamshidi,
Fazlollah Hashemzehi,
Amir Hossein Siadat,
Alireza Asemi Esfahani
Publication year - 2016
Publication title -
advanced biomedical research
Language(s) - English
Resource type - Journals
ISSN - 2277-9175
DOI - 10.4103/2277-9175.191002
Subject(s) - pemphigus vulgaris , desmoglein 3 , desmoglein 1 , prolactin , pemphigus , medicine , pathogenesis , desmoglein , antibody , etiology , immunology , autoantibody , hormone
Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris.Materials and Methods: Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris.Results: There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02, P = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09, P = 0.38).Conclusion: This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris