Open AccessFrom conventional therapy toward microRNA-based therapy in acute promyelocytic leukemia
Author(s) -
Naeim Ehtesham,
Mohammadreza Sharifi
Publication year - 2016
Publication title -
advanced biomedical research
Language(s) - English
Resource type - Journals
ISSN - 2277-9175
DOI - 10.4103/2277-9175.190996
Subject(s) - acute promyelocytic leukemia , medicine , microrna , malignancy , disease , oncology , acute leukemia , targeted therapy , bioinformatics , leukemia , cancer , biology , gene , biochemistry , retinoic acid
Acute promyelocytic leukemia (APL) is a hematopoietic malignancy that is known with its special cytogenetic feature. Several studies have surveyed expression signature of microRNAs (miRNAs) in APL patients, especially patients who are treated with conventional therapy of this disease. Using miRNAs as diagnostic or prognostic biomarkers in various cancers has been widely studied. Currently, most studies are focusing on exploiting miRNAs as therapeutic tools, and promising progress has been achieved in this field. Recently, studies in the field of miRNA-based therapy in APL have been started