Open AccessAscorbic acid effect on CIN incidence in diabetic patient after coronary angiography
Author(s) -
H Nough,
Roya Daryachahei,
Leila Hadiani,
Mohammad Reza Najarzadegan,
M Mirzaee,
Roya Hemayati,
Mahdy Meidani,
Roya Mousazadeh,
Seyedhmahdyeh Namayandeh
Publication year - 2016
Publication title -
advanced biomedical research
Language(s) - English
Resource type - Journals
ISSN - 2277-9175
DOI - 10.4103/2277-9175.180638
Subject(s) - medicine , ascorbic acid , nephropathy , creatinine , contrast induced nephropathy , saline , placebo , cardiac catheterization , renal function , randomized controlled trial , urology , surgery , gastroenterology , anesthesia , diabetes mellitus , endocrinology , pathology , chemistry , alternative medicine , food science
Background: This study aims to investigate the antioxidant effect of vitamin C in preventing contrast-induced nephropathy (CIN) in diabetic patients after catheterization.Materials and Methods: In a double blinded, randomized controlled trial, 90 diabetic patients who were referred for cardiac catheterization were randomly allocated into two arms of vitamin C (A) and placebo (B). The treatment arm (A) received 2 g of vitamin C orally 2 h before catheterization and the control group (B) received 2 g of oral placebo. Six hours before catheterization, patients received fluid resuscitation with normal saline (CIN was considered as a 25% rise in creatinine (Cr) level or an increase of 0.5 mg/dL in earlier creatinine). CIN was compared between groups. Before andthree days after catheterization. Serum Bun – Cr was measured and GFR were calculated. The results were compared between the two groups. Six hours before catheterization, patients received fluid resuscitation with normal saline CIN was compare between arms.Results: Mean GFR in group (A) before procedure was respectively 69.82±19.26 and after the treatment was 81.51±27.40 (P=0.001). But in group (B) it was 74.18±24.41 and 75.20±29.65 (P=0.747). Contrast-induced nephropathy was observed in 10 patients (12.3%) including 3 patients (7.7%) in group (A) and (16.7%, 7 patients) in group (B) (P=0.315).Conclusion: Ascorbic acid intake in diabetic patients prior to use of contrast agents can be effective in maintaining GFR, but the incidence of contrast-induced nephropathy is not associated with the consumption of ascorbic acid