Open AccessEffects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients
Author(s) -
Jafar Mehvari,
Fataneh Gholami Motlagh,
Mostafa Najafi,
Mohammad Reza Aghaye Ghazvini,
Amirmansour Alavi Naeini,
Mohamad Zare
Publication year - 2016
Publication title -
advanced biomedical research
Language(s) - English
Resource type - Journals
ISSN - 2277-9175
DOI - 10.4103/2277-9175.178780
Subject(s) - medicine , carbamazepine , oxidative stress , placebo , epilepsy , electroencephalography , vitamin e , refractory (planetary science) , vitamin c , glutathione , vitamin , anesthesia , antioxidant , psychiatry , biochemistry , pathology , chemistry , physics , alternative medicine , enzyme , astrobiology
Background: Oxidative stress has been a frequent finding in epileptic patients receiving antiepileptic drugs (AEDs). In this study, the influence of Vitamin E on the antiseizure activity and redox state of patients treated with carbamazepine, sodium valproate, and levetiracetam has been investigated.Materials and Methods: This double-blind, placebo-controlled trial was carried out on 65 epileptic patients with chronic antiepileptic intake. The subjects received 400 IU/day of Vitamin E or placebo for 6 months. Seizure frequency, electroencephalogram (EEG), and redox state markers were measured monthly through the study.Results: Total antioxidant capacity, catalase and glutathione were significantly higher in Vitamin E received group compared with controls (P < 0.05) whereas malodialdehyde levels did not differ between two groups (P < 0.07). Vitamin E administration also caused a significant decrease in the frequency of seizures (P < 0.001) and improved EEG findings (P = 0.001). Of 32 patients in case group, the positive EEG decreased in 16 patients (50%) whereas among 33 patients in control group only 4 patients (12.1%) showed decreased positive EEG.Conclusion: The results of this preliminary study indicate that coadministration of antioxidant Vitamin E with AEDs improves seizure control and reduces oxidative stress