Open AccessLeptin and its cardiovascular effects: Focus on angiogenesis
Author(s) -
Zoya Tahergorabi,
Majid Khazaei
Publication year - 2015
Publication title -
advanced biomedical research
Language(s) - English
Resource type - Journals
ISSN - 2277-9175
DOI - 10.4103/2277-9175.156526
Subject(s) - leptin , angiogenesis , homeostasis , energy homeostasis , endocrine system , medicine , hormone , endocrinology , receptor , immune system , glucose homeostasis , diabetes mellitus , obesity , immunology , insulin resistance
Leptin is an endocrine hormone synthesized by adipocytes. It plays a key role in the energy homeostasis in central and peripheral tissues and has additional roles are attributed to it, such as the regulation of reproduction, immune function, bone homeostasis, and angiogenesis. The plasma concentration of leptin significantly increases in obese individuals. In the present review, we give an introduction concerning leptin, its receptors, signaling pathways, and its effect on cardiovascular system, especially on angiogenesis