Open AccessA histomorphometric study of the effect of doxycycline and erythromycin on bone formation in dental alveolar socket of rat
Author(s) -
Mohammad Shahabooei,
Sayed Mohammad Razavi,
Mohsen Minaiyan,
Reza Birang,
Parichehr Behfarnia,
Jaber Yaghini,
Narges Naghsh,
Parichehr Ghalayani,
Samira Hajisadeghi
Publication year - 2015
Publication title -
advanced biomedical research
Language(s) - English
Resource type - Journals
ISSN - 2277-9175
DOI - 10.4103/2277-9175.153895
Subject(s) - medicine , dental alveolus , saline , doxycycline , erythromycin , dentistry , molar , antibiotics , anesthesia , chemistry , biochemistry
Background: The aim of the present study was to evaluate whether subantimicrobial doses of doxycycline (DOX) and erythromycin (EM) used for the treatment of peri-implant osteolysis due to their anti-osteoclastogenesis can interfere with the osseous wound healing process in rat alveolar socket. Materials and Methods: Forty-five male Wistar rats had their first maxillary right molar extracted and were divided into three groups. DOX and EM at the doses of 5 mg/kg/day orally (p.o.) and 2 mg/kg/day intraperitoneally (i.p.) were administered respectively to two separate groups for 7 days after operation. In the control group the animals received normal saline (5 ml/kg). Five rats were sacrificed at 7, 14 and 21 days post-extraction in each study group. A histomorphometric analysis was used to evaluate new bone formation inside the alveolar socket. Significant level was set at 0.05. Results: The findings showed that the percentage of new bone formation (NBF) enhanced significantly on days 7 and 14. There was no significant difference in the NBF between DOX and EM groups. Conclusion: Short-term treatment with both DOX and EM enhanced new bone formation without any advances in favor of each drug